SLC26A4
solute carrier family 26 member 4
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 7 (drug and xenobiotic transporters). Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Pendrin
- Function
Sodium-independent transporter of chloride and iodide. Mediates electroneutral chloride-bicarbonate, chloride-iodide and chloride-formate exchange with 1:1 stoichiometry. Mediates electroneutral iodide-bicarbonate exchange (By similarity).
- Subcellular location
Cell membrane; Apical cell membrane.
- Tissue specificity
Highly expressed in the kidney (at protein level). High expression in adult thyroid, lower expression in adult and fetal kidney and fetal brain. Not expressed in other tissues.
- Associated conditions
Pendred syndrome (PDS); Deafness, autosomal recessive, 4 (DFNB4).
Source: UniProtKB/Swiss-Prot O43511, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.
Written for the whole drug transporters family, not for SLC26A4 specifically.
Mentioned in 0 corpus records
No corpus record names SLC26A4 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).
Also in drug and xenobiotic transporters
All 62 genes- SLC6A4
solute carrier family 6 member 4
chr 17· Drug transporters· 10 records - ABCC2Powers
ATP binding cassette subfamily C member 2
chr 10· Drug transporters· 6 records - ABCC3Powers
ATP binding cassette subfamily C member 3
chr 17· Drug transporters· 5 records - ABCB1
ATP binding cassette subfamily B member 1
chr 7· Drug transporters· 3 records - ABCC5Powers
ATP binding cassette subfamily C member 5
chr 3· Drug transporters· 3 records - SLCO1B1Powers
solute carrier organic anion transporter family member 1B1
chr 12· Drug transporters· 4 records - SLC18A2
solute carrier family 18 member A2
chr 10· Drug transporters· 1 record - SLCO1B3
solute carrier organic anion transporter family member 1B3
chr 12· Drug transporters· 1 record
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