Pathway candidateNCBI-verifiedprotein-coding

SLC51B

SLC51 subunit beta

NCBI Gene: 123264 Ensembl GeneCards UniProt: Q86UW2

Pathway candidate — not linked to PFS or PSSD by any record here

SLC51B is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLC51B is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 15 (drug and xenobiotic transporters). Predicted to enable bile acid transmembrane transporter activity and protein heterodimerization activity. Involved in bile acid secretion.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Organic solute transporter subunit beta
Function: Essential component of the OST-alpha/OST-beta complex, a heterotetramer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. The OST-alpha/OST-beta complex efficiently transports the major species of bile acids (taurocholate). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). In the complex, SLC51B/OST-beta promotes the transmembrane translocation of bile acids. Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols. Able to transport eicosanoids such as prostaglandin E2 (By similarity).
Subcellular location: Basolateral cell membrane.
Tissue specificity: Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.
Associated conditions: Bile acid malabsorption, primary, 2 (PBAM2).

Source: UniProtKB/Swiss-Prot Q86UW2, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLC51B specifically.

Mentioned in 0 corpus records

No corpus record names SLC51B directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Organic solute transporter subunit beta
Function: Essential component of the OST-alpha/OST-beta complex, a heterotetramer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. The OST-alpha/OST-beta complex efficiently transports the major species of bile acids (taurocholate). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). In the complex, SLC51B/OST-beta promotes the transmembrane translocation of bile acids. Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols. Able to transport eicosanoids such as prostaglandin E2 (By similarity).
Subcellular location: Basolateral cell membrane.
Tissue specificity: Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.
Associated conditions: Bile acid malabsorption, primary, 2 (PBAM2).