SLC6A3
solute carrier family 6 member 3
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 5 (drug and xenobiotic transporters, neurotransmission). Encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Sodium-dependent dopamine transporter
- Function
Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).
- Subcellular location
Cell membrane; Cell projection, neuron projection; Cell projection, axon.
- Tissue specificity
Highly expressed in substantia nigra. Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level). Expressed in the striatum (at protein level).
- Associated conditions
Parkinsonism-dystonia 1, infantile-onset (PKDYS1).
Source: UniProtKB/Swiss-Prot Q01959, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism. Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).
Written for the whole drug transporters / neurotransmission family, not for SLC6A3 specifically.
Mentioned in 0 corpus records
No corpus record names SLC6A3 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters, Neurotransmission).
Also in drug and xenobiotic transporters
All 62 genes- SLC6A4
solute carrier family 6 member 4
chr 17· Drug transporters· 10 records - ABCC2Powers
ATP binding cassette subfamily C member 2
chr 10· Drug transporters· 6 records - ABCC3Powers
ATP binding cassette subfamily C member 3
chr 17· Drug transporters· 5 records - ABCB1
ATP binding cassette subfamily B member 1
chr 7· Drug transporters· 3 records - ABCC5Powers
ATP binding cassette subfamily C member 5
chr 3· Drug transporters· 3 records - SLCO1B1Powers
solute carrier organic anion transporter family member 1B1
chr 12· Drug transporters· 4 records - SLC18A2
solute carrier family 18 member A2
chr 10· Drug transporters· 1 record - SLCO1B3
solute carrier organic anion transporter family member 1B3
chr 12· Drug transporters· 1 record
Browse by family on the gene families page.