Pathway candidateNCBI-verifiedprotein-coding

SLCO1A2

solute carrier organic anion transporter family member 1A2

NCBI Gene: 6579 Ensembl GeneCards UniProt: P46721

Pathway candidate — not linked to PFS or PSSD by any record here

SLCO1A2 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLCO1A2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 12 (drug and xenobiotic transporters). Encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier organic anion transporter family member 1A2
Function (excerpt): Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane. Responsible for intestinal absorption of bile acids (By similarity). Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision. Involved in the uptake of clinically used drugs. Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine). Also transports prostaglandin E2.
Subcellular location: Cell membrane; Basal cell membrane.
Tissue specificity: Higher expression in the brain than in liver and kidney. Expressed in brain neurons in both cortex and hippocampus. Expressed in placental trophoblasts. Also expressed in lung and testes at lower levels. Expressed in the eye (at protein level). Expressed in the retina in the outer and inner nuclear layers, the inner plexiform layer and the ganglion cell layer. Expressed in liver and prostate. In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed in Leydig cells and within the tubules. Expressed in fetal brain and liver.

Source: UniProtKB/Swiss-Prot P46721, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLCO1A2 specifically.

Mentioned in 0 corpus records

No corpus record names SLCO1A2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier organic anion transporter family member 1A2
Function (excerpt): Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane. Responsible for intestinal absorption of bile acids (By similarity). Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision. Involved in the uptake of clinically used drugs. Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine). Also transports prostaglandin E2.
Subcellular location: Cell membrane; Basal cell membrane.
Tissue specificity: Higher expression in the brain than in liver and kidney. Expressed in brain neurons in both cortex and hippocampus. Expressed in placental trophoblasts. Also expressed in lung and testes at lower levels. Expressed in the eye (at protein level). Expressed in the retina in the outer and inner nuclear layers, the inner plexiform layer and the ganglion cell layer. Expressed in liver and prostate. In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed in Leydig cells and within the tubules. Expressed in fetal brain and liver.