Pathway candidateNCBI-verifiedprotein-coding

SLCO1C1

solute carrier organic anion transporter family member 1C1

NCBI Gene: 53919 Ensembl GeneCards UniProt: Q9NYB5

Pathway candidate — not linked to PFS or PSSD by any record here

SLCO1C1 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLCO1C1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 12 (drug and xenobiotic transporters). Encodes a member of the organic anion transporter family. The protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier organic anion transporter family member 1C1
Function: Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane. Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases. Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency. Transports T4 and E1S in a pH-insensitive manner. Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain.
Subcellular location: Cell membrane.
Tissue specificity: Highly expressed in brain and in Leydig cells in testis. Localized in nests of Leydig cells (at protein level). Expressed in choroid plexus (at protein level). Not strongly enriched in cerebral microvessels.

Source: UniProtKB/Swiss-Prot Q9NYB5, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLCO1C1 specifically.

Mentioned in 0 corpus records

No corpus record names SLCO1C1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Solute carrier organic anion transporter family member 1C1
Function: Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane. Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases. Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency. Transports T4 and E1S in a pH-insensitive manner. Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain.
Subcellular location: Cell membrane.
Tissue specificity: Highly expressed in brain and in Leydig cells in testis. Localized in nests of Leydig cells (at protein level). Expressed in choroid plexus (at protein level). Not strongly enriched in cerebral microvessels.