Pathway candidateNCBI-verifiedprotein-coding

SLCO2B1

solute carrier organic anion transporter family member 2B1

NCBI Gene: 11309 Ensembl GeneCards UniProt: O94956

Pathway candidate — not linked to PFS or PSSD by any record here

SLCO2B1 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLCO2B1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 11 (drug and xenobiotic transporters). This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier organic anion transporter family member 2B1
Function (excerpt): Mediates the Na(+)-independent transport of steroid sulfate conjugates and other specific organic anions. Responsible for the transport of estrone 3-sulfate (E1S) through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S). Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver. Mediates the intestinal uptake of sulfated steroids. Mediates the uptake of the neurosteroids DHEA-S and pregnenolone sulfate (PregS) into the endothelial cells of the blood-brain barrier as the first step to enter the brain. Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons.
Subcellular location: Cell membrane; Basal cell membrane; Basolateral cell membrane; Apical cell membrane.
Tissue specificity: Strongly expressed in the liver, at the sinusoidal membrane of the hepatocytes. Expressed in the kidney. Expressed in placental trophoblasts and syncytiotrophoblast. Expressed in the small intestine. Expressed in the blood-brain barrier, in endothelial cells of brain capillaries. Expressed in the retina, in the inner nuclear layer and the inner plexiform layer. Expressed in skelettal muscles. In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed within the tubules. Also expressed in pancreas, lung, heart, colon, ovary and spleen. Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and pancreas.

Source: UniProtKB/Swiss-Prot O94956, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLCO2B1 specifically.

Mentioned in 0 corpus records

No corpus record names SLCO2B1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier organic anion transporter family member 2B1
Function (excerpt): Mediates the Na(+)-independent transport of steroid sulfate conjugates and other specific organic anions. Responsible for the transport of estrone 3-sulfate (E1S) through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S). Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver. Mediates the intestinal uptake of sulfated steroids. Mediates the uptake of the neurosteroids DHEA-S and pregnenolone sulfate (PregS) into the endothelial cells of the blood-brain barrier as the first step to enter the brain. Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons.
Subcellular location: Cell membrane; Basal cell membrane; Basolateral cell membrane; Apical cell membrane.
Tissue specificity: Strongly expressed in the liver, at the sinusoidal membrane of the hepatocytes. Expressed in the kidney. Expressed in placental trophoblasts and syncytiotrophoblast. Expressed in the small intestine. Expressed in the blood-brain barrier, in endothelial cells of brain capillaries. Expressed in the retina, in the inner nuclear layer and the inner plexiform layer. Expressed in skelettal muscles. In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed within the tubules. Also expressed in pancreas, lung, heart, colon, ovary and spleen. Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and pancreas.