Pathway candidateNCBI-verifiedprotein-coding

SMARCB1

SWI/SNF related BAF chromatin remodeling complex subunit B1

NCBI Gene: 6598 Ensembl GeneCards UniProt: Q12824

Pathway candidate — not linked to PFS or PSSD by any record here

SMARCB1 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in SMARCB1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 22 (epigenetic regulation). The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Function (excerpt): Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).
Subcellular location: Nucleus.
Associated conditions: Rhabdoid tumor predisposition syndrome 1 (RTPS1); Schwannomatosis 1 (SWN1); Coffin-Siris syndrome 3 (CSS3).

Source: UniProtKB/Swiss-Prot Q12824, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for SMARCB1 specifically.

Mentioned in 0 corpus records

No corpus record names SMARCB1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Function (excerpt): Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).
Subcellular location: Nucleus.
Associated conditions: Rhabdoid tumor predisposition syndrome 1 (RTPS1); Schwannomatosis 1 (SWN1); Coffin-Siris syndrome 3 (CSS3).