Pathway candidateNCBI-verifiedprotein-coding

SMARCD2

SWI/SNF related BAF chromatin remodeling complex subunit D2

NCBI Gene: 6603 Ensembl GeneCards UniProt: Q92925

Pathway candidate — not linked to PFS or PSSD by any record here

SMARCD2 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in SMARCD2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 17 (epigenetic regulation). The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
Subcellular location: Nucleus.
Tissue specificity: Isoform 2 is expressed in the pancreas.
Associated conditions: Specific granule deficiency 2 (SGD2).

Source: UniProtKB/Swiss-Prot Q92925, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for SMARCD2 specifically.

Mentioned in 0 corpus records

No corpus record names SMARCD2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
Subcellular location: Nucleus.
Tissue specificity: Isoform 2 is expressed in the pancreas.
Associated conditions: Specific granule deficiency 2 (SGD2).