Pathway candidateNCBI-verifiedprotein-coding

SMARCE1

SWI/SNF related BAF chromatin remodeling complex subunit E1

NCBI Gene: 6605 Ensembl GeneCards UniProt: Q969G3

Pathway candidate — not linked to PFS or PSSD by any record here

SMARCE1 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in SMARCE1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 17 (epigenetic regulation). The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Function (excerpt): Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.
Subcellular location: Nucleus.
Associated conditions: Meningioma (MNGMA); Coffin-Siris syndrome 5 (CSS5).

Source: UniProtKB/Swiss-Prot Q969G3, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for SMARCE1 specifically.

Mentioned in 0 corpus records

No corpus record names SMARCE1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Function (excerpt): Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.
Subcellular location: Nucleus.
Associated conditions: Meningioma (MNGMA); Coffin-Siris syndrome 5 (CSS5).