Pathway candidateNCBI-verifiedprotein-coding

SRCAP

Snf2 related CREBBP activator protein

NCBI Gene: 10847 Ensembl GeneCards UniProt: Q6ZRS2

Pathway candidate — not linked to PFS or PSSD by any record here

SRCAP is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in SRCAP is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 16 (epigenetic regulation). Encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Chromatin remodeling protein SRCAP
Function: Acts both as a chromatin remodeler and transcription coregulator. Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes expression through chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.
Subcellular location: Nucleus.
Associated conditions: Floating-Harbor syndrome (FLHS); Developmental delay, hypotonia, musculoskeletal defects, and behavioral abnormalities (DEHMBA).

Source: UniProtKB/Swiss-Prot Q6ZRS2, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for SRCAP specifically.

Mentioned in 0 corpus records

No corpus record names SRCAP directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Chromatin remodeling protein SRCAP
Function: Acts both as a chromatin remodeler and transcription coregulator. Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes expression through chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.
Subcellular location: Nucleus.
Associated conditions: Floating-Harbor syndrome (FLHS); Developmental delay, hypotonia, musculoskeletal defects, and behavioral abnormalities (DEHMBA).