Pathway candidateNCBI-verifiedprotein-coding

SULT1A1

sulfotransferase family 1A member 1

NCBI Gene: 6817 Ensembl GeneCards UniProt: P50225

Pathway candidate — not linked to PFS or PSSD by any record here

SULT1A1 is in the library because it belongs to the conjugation & clearance family. No study, report or commentary in the corpus names it, so a variant in SULT1A1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 16 (steroid conjugation and clearance). Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Sulfotransferase 1A1
Function (excerpt): Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones. Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis. May play a role in gut microbiota-host metabolic interaction.
Subcellular location: Cytoplasm.
Tissue specificity: Liver, lung, adrenal, brain, platelets and skin.

Source: UniProtKB/Swiss-Prot P50225, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Steroid clearance is the exit route for androgens and their metabolites — the pathway at the center of Powers' PFS model (defective glucuronidation/sulfation trapping androgens intracellularly). Gut bacterial enzymes can undo this clearance, linking it to the microbiome thread.

Written for the whole conjugation & clearance family, not for SULT1A1 specifically.

Mentioned in 0 corpus records

No corpus record names SULT1A1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Conjugation & clearance).

Also in steroid conjugation and clearance

All 31 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Sulfotransferase 1A1
Function (excerpt): Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones. Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis. May play a role in gut microbiota-host metabolic interaction.
Subcellular location: Cytoplasm.
Tissue specificity: Liver, lung, adrenal, brain, platelets and skin.

Why its pathway is in the library

Written for the whole conjugation & clearance family, not for SULT1A1 specifically.