SULT1A2
sulfotransferase family 1A member 2
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 16 (steroid conjugation and clearance). Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Sulfotransferase 1A2
- Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
- Subcellular location
Cytoplasm.
Source: UniProtKB/Swiss-Prot P50226, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Steroid clearance is the exit route for androgens and their metabolites — the pathway at the center of Powers' PFS model (defective glucuronidation/sulfation trapping androgens intracellularly). Gut bacterial enzymes can undo this clearance, linking it to the microbiome thread.
Written for the whole conjugation & clearance family, not for SULT1A2 specifically.
Mentioned in 0 corpus records
No corpus record names SULT1A2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Conjugation & clearance).
Also in steroid conjugation and clearance
All 31 genes- UGT2B17Powers
UDP glucuronosyltransferase family 2 member B17
chr 4· Conjugation & clearance· 30 records - UGT2B15Powers
UDP glucuronosyltransferase family 2 member B15
chr 4· Conjugation & clearance· 13 records - AKR1C2Powers
aldo-keto reductase family 1 member C2
chr 10· Steroid synthesis· 12 records - UGT2B7Powers
UDP glucuronosyltransferase family 2 member B7
chr 4· Conjugation & clearance· 11 records - AKR1C3Powers
aldo-keto reductase family 1 member C3
chr 10· Steroid synthesis· 9 records - AKR1C4Powers
aldo-keto reductase family 1 member C4
chr 10· Steroid synthesis· 8 records - AKR1C1Powers
aldo-keto reductase family 1 member C1
chr 10· Steroid synthesis· 7 records - SULT2A1Powers
sulfotransferase family 2A member 1
chr 19· Conjugation & clearance· 7 records
Browse by family on the gene families page.