Pathway candidateNCBI-verifiedprotein-coding

SULT2B1

sulfotransferase family 2B member 1

NCBI Gene: 6820 Ensembl GeneCards UniProt: O00204

Pathway candidate — not linked to PFS or PSSD by any record here

SULT2B1 is in the library because it belongs to the conjugation & clearance family. No study, report or commentary in the corpus names it, so a variant in SULT2B1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 19 (steroid conjugation and clearance). Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Sulfotransferase 2B1
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol. Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Preferentially sulfonates cholesterol, while it also has significant activity with pregnenolone and DHEA. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation.
Subcellular location: Cytoplasm, cytosol; Microsome; Nucleus.
Tissue specificity: Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.
Associated conditions: Ichthyosis, congenital, autosomal recessive 14 (ARCI14).

Source: UniProtKB/Swiss-Prot O00204, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Steroid clearance is the exit route for androgens and their metabolites — the pathway at the center of Powers' PFS model (defective glucuronidation/sulfation trapping androgens intracellularly). Gut bacterial enzymes can undo this clearance, linking it to the microbiome thread.

Written for the whole conjugation & clearance family, not for SULT2B1 specifically.

Mentioned in 0 corpus records

No corpus record names SULT2B1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Conjugation & clearance).

Also in steroid conjugation and clearance

All 31 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Sulfotransferase 2B1
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol. Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Preferentially sulfonates cholesterol, while it also has significant activity with pregnenolone and DHEA. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation.
Subcellular location: Cytoplasm, cytosol; Microsome; Nucleus.
Tissue specificity: Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.
Associated conditions: Ichthyosis, congenital, autosomal recessive 14 (ARCI14).

Why its pathway is in the library

Written for the whole conjugation & clearance family, not for SULT2B1 specifically.