Pathway candidateNCBI-verifiedprotein-coding

SUMF1

sulfatase modifying factor 1

NCBI Gene: 285362 Ensembl GeneCards UniProt: Q8NBK3

Pathway candidate — not linked to PFS or PSSD by any record here

SUMF1 is in the library because it belongs to the conjugation & clearance family. No study, report or commentary in the corpus names it, so a variant in SUMF1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (steroid conjugation and clearance). Encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Formylglycine-generating enzyme
Function: Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE.
Pathway: Protein modification; sulfatase oxidation.
Subcellular location: Endoplasmic reticulum lumen.
Tissue specificity: Ubiquitous. Highly expressed in kidney, pancreas and liver. Detected at lower levels in leukocytes, lung, placenta, small intestine, skeletal muscle and heart.
Associated conditions: Multiple sulfatase deficiency (MSD).

Source: UniProtKB/Swiss-Prot Q8NBK3, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Steroid clearance is the exit route for androgens and their metabolites — the pathway at the center of Powers' PFS model (defective glucuronidation/sulfation trapping androgens intracellularly). Gut bacterial enzymes can undo this clearance, linking it to the microbiome thread.

Written for the whole conjugation & clearance family, not for SUMF1 specifically.

Mentioned in 0 corpus records

No corpus record names SUMF1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Conjugation & clearance).

Also in steroid conjugation and clearance

All 31 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Formylglycine-generating enzyme
Function: Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE.
Pathway: Protein modification; sulfatase oxidation.
Subcellular location: Endoplasmic reticulum lumen.
Tissue specificity: Ubiquitous. Highly expressed in kidney, pancreas and liver. Detected at lower levels in leukocytes, lung, placenta, small intestine, skeletal muscle and heart.
Associated conditions: Multiple sulfatase deficiency (MSD).

Why its pathway is in the library

Written for the whole conjugation & clearance family, not for SUMF1 specifically.