Pathway candidateNCBI-verifiedprotein-coding

SUV39H1

SUV39H1 histone lysine methyltransferase

NCBI Gene: 6839 Ensembl GeneCards UniProt: O43463

Pathway candidate — not linked to PFS or PSSD by any record here

SUV39H1 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in SUV39H1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome X (epigenetic regulation). Encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Histone-lysine N-methyltransferase SUV39H1
Function (excerpt): Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions (By similarity). H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.
Subcellular location: Nucleus; Chromosome; Nucleus lamina; Nucleus, nucleoplasm; Chromosome, centromere; Cytoplasmic vesicle, phagosome lumen; Cell membrane.

Source: UniProtKB/Swiss-Prot O43463, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for SUV39H1 specifically.

Mentioned in 0 corpus records

No corpus record names SUV39H1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Histone-lysine N-methyltransferase SUV39H1
Function (excerpt): Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions (By similarity). H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.
Subcellular location: Nucleus; Chromosome; Nucleus lamina; Nucleus, nucleoplasm; Chromosome, centromere; Cytoplasmic vesicle, phagosome lumen; Cell membrane.