UGDH
UDP-glucose 6-dehydrogenase
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 4 (steroid conjugation and clearance). The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
UDP-glucose 6-dehydrogenase
- Function
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development.
- Pathway
Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.
- Tissue specificity
Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon. Widely expressed.
- Associated conditions
Developmental and epileptic encephalopathy 84 (DEE84).
Source: UniProtKB/Swiss-Prot O60701, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Steroid clearance is the exit route for androgens and their metabolites — the pathway at the center of Powers' PFS model (defective glucuronidation/sulfation trapping androgens intracellularly). Gut bacterial enzymes can undo this clearance, linking it to the microbiome thread.
Written for the whole conjugation & clearance family, not for UGDH specifically.
Mentioned in 0 corpus records
No corpus record names UGDH directly yet. It is in the library because it sits in a pathway the corpus tracks (Conjugation & clearance).
Also in steroid conjugation and clearance
All 31 genes- UGT2B17Powers
UDP glucuronosyltransferase family 2 member B17
chr 4· Conjugation & clearance· 30 records - UGT2B15Powers
UDP glucuronosyltransferase family 2 member B15
chr 4· Conjugation & clearance· 13 records - AKR1C2Powers
aldo-keto reductase family 1 member C2
chr 10· Steroid synthesis· 12 records - UGT2B7Powers
UDP glucuronosyltransferase family 2 member B7
chr 4· Conjugation & clearance· 11 records - AKR1C3Powers
aldo-keto reductase family 1 member C3
chr 10· Steroid synthesis· 9 records - AKR1C4Powers
aldo-keto reductase family 1 member C4
chr 10· Steroid synthesis· 8 records - AKR1C1Powers
aldo-keto reductase family 1 member C1
chr 10· Steroid synthesis· 7 records - SULT2A1Powers
sulfotransferase family 2A member 1
chr 19· Conjugation & clearance· 7 records
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