Pathway candidateNCBI-verifiedprotein-coding

UGP2

UDP-glucose pyrophosphorylase 2

NCBI Gene: 7360 Ensembl GeneCards UniProt: Q16851

Pathway candidate — not linked to PFS or PSSD by any record here

UGP2 is in the library because it belongs to the conjugation & clearance family. No study, report or commentary in the corpus names it, so a variant in UGP2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 2 (steroid conjugation and clearance). The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: UTP--glucose-1-phosphate uridylyltransferase
Function: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.
Pathway: Glycan biosynthesis; glycogen biosynthesis.
Subcellular location: Cytoplasm.
Tissue specificity: Highly expressed in various brain regions. Expressed in amygdala, anterior cingulate cortex, caudate, cerebellar hemisphere, cerebellum, cortex, frontal cortex, hippocampus, hypothalamus, nucleus accumbens, putamen, spinal cord and substantia nigra. Also widely expressed among other tissues, including liver, heart, placenta, lung, kidney, pancreas and skeletal muscle.
Associated conditions: Developmental and epileptic encephalopathy 83 (DEE83).

Source: UniProtKB/Swiss-Prot Q16851, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Steroid clearance is the exit route for androgens and their metabolites — the pathway at the center of Powers' PFS model (defective glucuronidation/sulfation trapping androgens intracellularly). Gut bacterial enzymes can undo this clearance, linking it to the microbiome thread.

Written for the whole conjugation & clearance family, not for UGP2 specifically.

Mentioned in 0 corpus records

No corpus record names UGP2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Conjugation & clearance).

Also in steroid conjugation and clearance

All 31 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: UTP--glucose-1-phosphate uridylyltransferase
Function: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.
Pathway: Glycan biosynthesis; glycogen biosynthesis.
Subcellular location: Cytoplasm.
Tissue specificity: Highly expressed in various brain regions. Expressed in amygdala, anterior cingulate cortex, caudate, cerebellar hemisphere, cerebellum, cortex, frontal cortex, hippocampus, hypothalamus, nucleus accumbens, putamen, spinal cord and substantia nigra. Also widely expressed among other tissues, including liver, heart, placenta, lung, kidney, pancreas and skeletal muscle.
Associated conditions: Developmental and epileptic encephalopathy 83 (DEE83).

Why its pathway is in the library

Written for the whole conjugation & clearance family, not for UGP2 specifically.