Effects of indomethacin on plasma homovanillic acid concentration in normal subjects: a study of prostaglandin-dopamine interactions
R S Kahn, M Davidson, P Kanof, R T McQueeney, R R Singh, K L Davis
Psychopharmacology (Berl)1991
Summary (paraphrased)
Controlled clinical trial in eight normal subjects showing that a single 150 mg oral dose of indomethacin significantly raised plasma homovanillic acid (pHVA, a dopamine metabolite) versus placebo. The authors interpreted this as evidence that prostaglandin synthesis inhibition increases central dopamine turnover in humans, paralleling animal findings.
Why it’s in the corpus
Human pharmacology data on a prostaglandin–dopamine interaction: relevant to dopamine-centered PSSD hypotheses (cf. DISC-015) and to indomethacin's neuropharmacological profile. NOTE: discord label 'Gene variants' is incorrect; PMID 2006246 is this indomethacin–dopamine study.