Potential role of CYP2D6 in the central nervous system
Cheng J, Zhen Y, Miksys S, Beyoğlu D, Krausz KW, Tyndale RF, Yu A, Idle JR, Gonzalez FJ
Xenobiotica2013
Summary (paraphrased)
Mouse study using a transgenic human-CYP2D6 model, finding that human CYP2D6 is expressed not only in liver but also in brain, where it altered serotonin and metabolite levels plus broader brain metabolomic profiles, and shifted anxiety-related behavior. The authors conclude CYP2D6 plays neurophysiological roles beyond hepatic drug metabolism and propose the transgenic mouse as a tool for studying them.
Why it’s in the corpus
CYP2D6 metabolizes many SSRIs and shows brain activity linked to serotonin turnover and anxiety — relevant to pharmacogenetic differences in SSRI exposure/withdrawal and PSSD susceptibility hypotheses.
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