Have gender dysphoria, hypermobile, ADHD or autism… / The non-AD of trans…
u/drwillpowers
r/DrWillPowerscirca 2023 (post IDs 12g4rop / wybnef era)
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Summary (paraphrased)
Powers described a striking comorbidity cluster in his transgender patient population — autism, ADHD, hypermobility, POTS/dysautonomia, congenital adrenal hyperplasia, Hashimoto's thyroiditis, and GI issues — and reported discovering relevant mutations in his own genome, leading him to trial methylated B vitamins (L-methylfolate, methylcobalamin) with self-reported mental-health benefit. While not about PFS/PSSD directly, it illustrates his broader method: mining patient genomes for shared variants behind drug-response and neuropsychiatric phenotypes.
Why it’s in the corpus
Context for Powers' genetics-first methodology that underpins his PFS/PSSD mutation-hunting (DWP-001, DWP-003). Relevant to the corpus's "genetic relationships" axis as background on his approach.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- Powers gene claim
MTHFR — "two bad copies" (self-reported); common MTHFR SNPs (e.g., rs1801131, rs1801133) in patients
Confidence: direct (adjacent)
Powers reported finding MTHFR mutations at high rates in his transgender patient population and in himself (two bad copies), and trialed L-methylfolate plus methylcobalamin with self-reported mental-health benefit. He hypothesized methylation defects amplify…
MTHFRPGL-MTHFRcirca 2023PFSCore corpus - Peer-reviewed paper
Association between MTHFR C677T polymorphism and depression: An updated meta-analysis of 26 studies
Yile Wu, Xiuxiu Ding, Yehuan Sun, Huiyun Yang, Jian Chen, Xue Yan Zhao, Yuhong Jiang, Xiaoling Lv, Zhenqiang Wu · Progress in Neuro-Psychopharmacology and Biological Psychiatry
Prior studies of the MTHFR C677T polymorphism and depression had given inconclusive results, so the authors pooled 26 studies comprising 4,992 depression cases and 17,082 controls. The T allele was associated with increased depression risk overall (TT vs CC…
MTHFRMECH-0412013Systems review · Oct 2026 - Powers · Reddit commentCurated Powers pick
Re: Any chance someone could help me make sense of a…
u/drwillpowers · r/DrWillPowers
Reply to someone anxious about SNP-array results. Powers says the SNPs flagged by consumer tools are well-known common glitches carried by many healthy people with good outcomes; the variants that matter don't appear on SNP arrays at all. His example: a PFS…
UGT2B17PRH-13302026-04-07T01:29:40ZPFSPowers Reddit history