Differential Gene Expression in Post-Finasteride Syndrome Patients
Skyler Howell; Weitao Song; Alexander W. Pastuszak; Mohit Khera
The Journal of Sexual Medicine2021
Summary (paraphrased)
This Baylor-affiliated team compared gene expression in penile skin cells from 26 men with post-finasteride syndrome against 26 healthy controls. They found 1,446 genes over-expressed and 2,318 under-expressed in the PFS group, with the androgen receptor gene notably more active despite no corresponding rise in circulating androgen levels. The authors interpret the pattern as evidence that PFS has a real, tissue-localized biological basis rather than a purely psychological one. The work is limited to penile skin tissue, so it may not capture systemic effects. It remains a landmark molecular study in a field short on mechanistic data.
Why it’s in the corpus
Key molecular evidence for a biological basis of PFS, showing thousands of differentially expressed genes and elevated androgen receptor activity in affected tissue.
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