Anyone out there with PFS/PSSD/Post-drug who has developed osteoporosis or hypermobility since the incident?
u/drwillpowers
r/DrWillPowers2026-07-22T16:59:32Z
Dr Will Powers’ own statements and theorizing
Summary (paraphrased)
Post body unavailable. From the title, Powers surveyed the community for PFS/PSSD/post-drug patients who developed osteoporosis or hypermobility after their onset event. This directly probes the connective-tissue dimension of his model — the "melty" phenotype (PRH-1081), where he reported reversing hypermobility and connective-tissue/cortisol problems in patients — and suggests he was investigating whether bone-density loss and joint hypermobility are systematic post-drug sequelae, possibly tied to cortisol-feedback disruption. The responses could not be recovered.
Key points (paraphrased)
- Community survey: post-onset osteoporosis or hypermobility in PFS/PSSD/post-drug patients.
- Probes the connective-tissue ("melty") phenotype systematically.
- Possible cortisol-feedback / bone-density mechanism under investigation.
Why it’s in the corpus
The survey counterpart to his "melty" phenotype claims (PRH-1081) — shows him testing whether connective-tissue damage is a systematic feature rather than isolated cases. Relevant to the corpus's phenotype-expansion thread; re-fetch for responses.
Original post textVerbatim text recovered via the r.genit.al mirror; other users’ names removed.ShowHide
Original post by Powers — full self-text recovered from the r.genit.al mirror on 2026-10-07 (the export captured the title only):
I have lately been horrified to discover some of my PFS/PSSD patients are to their own surprise, hypermobile, and one recently had an absurdly bad DEXA. while i await dexa results on some other patients, I'm wondering if anyone else has had issues with:
Osteopenia/osteoporosis, or "you know, I've had a lot of fractures since getting PFS/PSSD" Hypermobility : Everyone says "I"m not hypermobile" until I bend their thumb to their wrist or extend their elbow past 180 degrees and then they go "oh shit". So check all the things:
https://www.ehlers-danlos.com/assessing-joint-hypermobility/
If my mechanistic theory is correct, a subset of PFS/PSSD/Post-Druggies (Someone please give me a better generic name for this, as I can't keep writing Accutane/LionsMane/etc), should have these problems, and I just haven't perhaps been looking for it directly like I am now. I'd like to not have to wait 8 weeks to get my answer to this, so if this is you, let me know below (or if not!)
Also, the longer you've had it, the more likely this should be, FYI.
- Dr Powers
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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