Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity
Kawata H, Ishikura N, Watanabe M, Nishimoto A, Tsunenari T, Aoki Y
Prostate2010
Summary (paraphrased)
Preclinical prostate-cancer study in which prolonged bicalutamide exposure produced a resistant cell subline that overexpressed androgen receptor protein and phosphorylated AR, proliferating at tenfold lower androgen concentrations than parent cells — without AR gene mutation or amplification. Bicalutamide even stimulated proliferation of the resistant cells, showing the receptor itself had become the hypersensitivity driver.
Why it’s in the corpus
Demonstrates that chronic anti-androgen exposure can leave behind persistent AR upregulation and hypersensitivity to low androgens — a receptor-adaptation paradigm directly analogous to post-antiandrogen persistent syndromes such as PFS.
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