Re: Dr. Powers' opinion on FMT?
u/drwillpowers
r/DrWillPowers2026-08-08T15:11:58Z
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Summary (paraphrased)
Asked for his opinion on fecal microbiota transplant (FMT), Powers said it simply alters the microbiota, which alters beta-glucuronidase production, which in turn determines how much glucuronidated hormone is de-conjugated in the gut and reabsorbed to add to the patient's metabolite pile. In theory, he said, a transplant could make a patient worse or better depending on the strain received. He contrasted this unpredictability with over-the-counter calcium D-glucarate, which always inhibits beta-glucuronidase, and said that is why he does not send patients for "poop transplants."
Key points (paraphrased)
- FMT's effect runs through microbiota → beta-glucuronidase → glucuronidated-hormone reabsorption.
- Outcome is strain-dependent: could worsen or improve the metabolite pile.
- CDG preferred: it always inhibits beta-glucuronidase, unlike the unpredictable transplant.
- He does not refer patients for FMT.
Why it’s in the corpus
A concise clinical-position statement on the gut axis of his model — FMT rejected as too unpredictable, CDG endorsed as the reliable beta-glucuronidase inhibitor. Relevant to the corpus's treatment-observation thread and the microbiome sub-theme (cf. PRH-1255).
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to a community member:
I’m a woman with PSSD. I don’t believe I have NCAH, but I just got my WGS back and one of the initial reports says I’m a carrier for a gene related to 21-Hydroxylase-Deficient Congenital Adrenal Hyperplasia.
Variant Identifier: rs6471 , RCV000012934
Your Data: GT
Risk Status: Likely Carrier
Gene: CYP21A2
The variant rs6471 in CYP21A2 is often associated with non-classic forms of CAH, which tend to have milder symptoms that may present later in life.
Ran it through GENE.IOBIO:
Gene: CYP21A2
Variant: c.844G>T
Protein: p.Val282Leu
rsID: rs6471
Zygosity: Het
Ref Allele: G
Alt Allele: T
Freq: 1.09% (gnomAD genomes v4, 0.0109 allele frequency)
REVEL: 0.311
I have some salt craving and low blood pressure, but not really any of the other developmental symptoms of NCAH. It says #1 Phenolyzer in Gene.iobio for Congenital Adrenal Hyperplasia and that it’s listed as pathogenic/likely pathogenic. But REVEL score isn’t very high. Not sure if this is helpful.
(Parent context recovered from the r.genit.al mirror on 2026-10-07; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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