Re: Cure for PFS

Powers laid out three PFS phenotypes and their prognoses: the neurosteroid phenotype, which he considers recoverable in almost all cases since he has never seen anyone permanently stuck in it; the "melty" phenotype of skin/connective-tissue damage, where he says he has already reversed hypermobility and connective-tissue/cortisol problems in patients (though severe scarring such as facial striae is probably only improvable, e.g., with laser), while the cortisol feedback-loop problem is breakable; and androgenic silencing, which he believes is fixable whenever a "window" can be achieved, being essentially a metabolic trap or self-reinforcing feedback loop. He described his then-current cure theory — drain every androgenic metabolite from the body, track 3A-ADG and other labs as they fall, and let the system fully reset — saying he would know in 4–5 weeks whether it works, while flagging epigenetic reprogramming during the state of cellular extremis as his main concern. He stressed PFS is never truly "curable" in the sense of permanent immunity: the vulnerable genetics remain, so a sufficient re-exposure could restart the loop — likening it to a managed seizure disorder, where knowing one's triggers prevents recurrence and the person otherwise feels as they did before 5ARI exposure, without the windows-and-crashes oscillation.