Re: Why do people feel better on anti androgens in pfs…
u/drwillpowers
r/DrWillPowers2026-04-11T18:45:09Z
Dr Will Powers’ own statements and theorizing
Summary (paraphrased)
Reply (partly in Spanish, with complaints about Reddit's auto-translation) to a question about anti-androgens and PFS. Powers confirms that androgenic trapping in skin — secondary to transporter defects and differential enzyme/transporter expression in skin cells — appears directly related to severe cystic acne in some people. He then states his main theory of post-Accutane syndrome: in some people (himself included) isotretinoin epigenetically and permanently reduces those transporters' expression, curing the acne; in others it further weakens an already compromised system to near zero, inducing the syndrome. He acknowledges he has no Accutane-patient genomes to test this and that it remains just an idea.
Key points (paraphrased)
- Androgenic trapping in skin linked to severe cystic acne via transporter defects.
- PAS theory: epigenetic transporter downregulation — curative in some, system-collapsing in the already-compromised.
- No Accutane genomes available; explicitly untested hypothesis.
Why it’s in the corpus
The most direct statement of Powers' post-Accutane mechanism (epigenetic transporter suppression), with his own case as the positive-control example — extends the corpus's post-drug-syndrome coverage to isotretinoin with a clear tested/untested boundary.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to a community member:
En mi caso con 41 años y SPF, homocisteína alta, hierro bajo, tibc bajo, vpm bajo. También he sufrido de acné desde siempre, lo cual como indica parece estar ligado con algunas personas que desarrollamos SPF. Muchas gracias por todo su trabajo doctor, ojalá consigamos una cura.
(Parent context recovered from the r.genit.al mirror on 2026-10-07; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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