Re: Dalla comunit%C3%A0 drwillpowers su reddit post…
u/drwillpowers
r/DrWillPowers2026-09-25T15:23:08Z
Dr Will Powers’ own statements and theorizing
Summary (paraphrased)
In the r/AccutaneRecovery cross-post thread, Powers states he sees two distinct post-accutane syndromes: one essentially identical to PSSD (mostly sexual symptoms), another of physical degeneration — collagen, skin, and joint damage. Since isotretinoin is known to alter epigenetics and terminate cell lines, he considers epigenetic change in PAS "almost guaranteed"; the open questions are whether those changes matter and whether they are reversible. He notes his data is thin — only two accutane patients — both with skin/connective-tissue issues and very elevated MMP-9 (in blood, and in one case stool), results their ordering doctors dismissed as irrelevant.
Key points (paraphrased)
- Two PAS syndromes distinguished: PSSD-like (sexual) vs degenerative (collagen/skin/joint).
- Epigenetic change in PAS considered "almost guaranteed" given isotretinoin's known effects; reversibility open.
- MMP-9 elevation in his two cases — dismissed by the ordering doctors.
- Data admittedly thin: no PAS genomes yet.
- Newest archive entry in tranche 2 (~11 days old at curation).
Why it’s in the corpus
The PAS taxonomy — the basis for splitting post-accutane presentations — plus the MMP-9 signal. Documents both the claim and its thin evidence base, in his own framing.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to [username removed], the cross-poster, who thanked him, described the subreddit's year-long admin vacuum and the new r/AccutaneSyndrome, and asked about MMP-9 testing specifics and the theory that isotretinoin is stored in the liver with impaired bile flow keeping it in circulation.
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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