Re: Why do people feel better on anti androgens in pfs…
u/drwillpowers
r/DrWillPowers2026-04-11T18:46:15Z
Dr Will Powers’ own statements and theorizing
Summary (paraphrased)
Replying in Spanish to a Spanish-speaking commenter, Powers states his primary PAS theory: in some people accutane epigenetically and permanently tones down androgen-export transporters — curing acne in those with overactive transport, but in people with an already-weak system cranking it down to near zero and inducing the syndrome. He explicitly flags the theory as untested: no PAS genomes and no post-accutane patients yet — "just a random thought."
Key points (paraphrased)
- Primary PAS theory: accutane epigenetically and permanently downregulates androgen-export transporters.
- Therapeutic in overactive-transport acne; catastrophic in already-weak systems.
- Explicitly untested — no PAS genomes or patients; flagged as a random thought.
- Honest uncertainty preserved alongside the hypothesis.
Why it’s in the corpus
The PAS mechanism hypothesis in its most compact form, honestly marked as untested. The corpus should preserve both the hypothesis and the uncertainty flag together.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to [username removed], who wrote in Spanish (41 years old, lifelong acne, high homocysteine, low iron) thanking him and linking their case to his acne–androgen framing, in the anti-androgens thread.
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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