Re: Why do people feel better on anti androgens in pfs…
u/drwillpowers
r/DrWillPowers2026-04-10T17:28:59Z
Dr Will Powers’ own statements and theorizing
Summary (paraphrased)
In the "why do anti-androgens help" thread, Powers reasons through a case: a gay man with severe lifelong cystic acne but low muscle mass and low testosterone may have an ABCC transporter defect trapping androgens in skin while starving the rest of the body — tissue-specific androgen overdose alongside systemic underdose. He notes that accutane's exact acne-remodeling mechanism is still not fully elucidated, and wonders whether accutane's epigenetic modulation of skin transporters, applied to an already-weak system, could produce PAS by the same logic as PFS: a drug added to a PFS-like system, worsening it by epigenetic modification.
Key points (paraphrased)
- ABCC defect hypothesis: androgens trapped in skin, systemic starvation — the acne–androgen paradox resolved.
- Tissue-specific overdose coexisting with systemic underdose.
- Accutane's acne-remodeling mechanism acknowledged as not fully elucidated.
- PAS sketched as transporter-modulation on an already-weak system — PFS logic via epigenetics.
- Explicitly spitballing; far from conclusive proof.
Why it’s in the corpus
The ABCC tissue-trapping mechanism and the acne–androgen paradox, bridging to PAS. Shows the model's extension from systemic clearance to tissue-specific transporter defects.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to [username removed], who asked whether Powers has said anything about post-accutane syndrome, in the thread "Why do people feel better on anti androgens in PFS?" (OP [username removed]: UGT mutation, feels better on anti-androgens but crashes on them).
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- Powers · Reddit commentCurated Powers pick
Re: Why do people feel better on anti androgens in pfs…
u/drwillpowers · r/DrWillPowers
Reply (partly in Spanish, with complaints about Reddit's auto-translation) to a question about anti-androgens and PFS. Powers confirms that androgenic trapping in skin — secondary to transporter defects and differential enzyme/transporter expression in skin…
PRH-12692026-04-11T18:45:09ZPFSPRSDPowers Reddit history - Powers · Reddit commentCurated Powers pick
Re: Why do people feel better on anti androgens in pfs…
u/drwillpowers · r/DrWillPowers
Replying in Spanish to a Spanish-speaking commenter, Powers states his primary PAS theory: in some people accutane epigenetically and permanently tones down androgen-export transporters — curing acne in those with overactive transport, but in people with an…
PRH-15262026-04-11T18:46:15ZPFSPRSDPowers Reddit history - Powers gene claim
ABCC (family) — unspecified
Confidence: interview
ABCC intracellular transporter genes are among the key gene classes in his experimentally verifiable mechanism, alongside UGTs and the epigenetic genes above.
PGL-ABCC-family2026-04-29PFSCore corpus