Re: Im starting to see trends in pssd genomes this is…
u/drwillpowers
r/DrWillPowers2026-06-13T15:48:20Z
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Summary (paraphrased)
Asked whether DHEA is still used alongside progesterone/pregnenolone for neurosteroid-type patients, Powers splits PSSD into androgenic-metabolite vs strictly-neurosteroid cases. Pregnenolone: yes for strictly-neurosteroid PSSD — it backfills the DHEA precursor pool, his "champagne tower" image (filling the tower midway so upstream synthesis isn't "stolen" for non-neurosteroid molecules) — but no if androgenic metabolite buildup is present, since it would add A4/T/DHT precursors and worsen the load.
Key points (paraphrased)
- PSSD subtyping: androgenic-metabolite vs strictly-neurosteroid cases.
- Pregnenolone rationale: backfill the DHEA pool; prevent precursor "steal" (champagne-tower image).
- Contraindicated with androgenic metabolite buildup — it adds A4/T/DHT precursors.
- Treatment logic follows subtyping; one protocol does not fit all.
- DBH thread context: low HVA (dopamine metabolite) as the emerging PSSD DUTCH signal.
Why it’s in the corpus
PSSD subtyping with direct treatment-logic consequences — the same precursor can help or harm depending on subtype. Documents the DBH/HVA genome-trend thread context.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to [username removed], who asked whether DHEA is still used alongside progesterone/pregnenolone for neurosteroid types, in Powers' DBH genome-trend thread (low dopamine metabolite HVA as the common PSSD DUTCH finding).
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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