Re: Im starting to see trends in pssd genomes this is…
u/drwillpowers
r/DrWillPowers2026-06-12T17:40:28Z
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Summary (paraphrased)
Comment in a thread on emerging trends in PSSD genomes involving the DBH gene. Powers notes that several PSSD patients have volunteered for the temporary chemical-castration trial if his other PSSD approaches don't work. He says he's increasingly convinced of a Venn-diagram overlap between PFS and PSSD — possibly a hybrid "PFSSD" state — and observes that a number of SSRIs interact with transporter mechanisms and with sex-hormone/cholesterol-like metabolism, which would fit a shared mechanism.
Key points (paraphrased)
- PSSD genome trends emerging, including DBH.
- PSSD castration-trial volunteers lined up.
- Proposed PFS/PSSD overlap ("PFSSD") supported by SSRIs' known interactions with transporters and steroid/cholesterol metabolism.
Why it’s in the corpus
Powers' rationale for a unified PFS/PSSD ("PFSSD") entity grounded in SSRI pharmacology intersecting transporter and steroid metabolism — a key genetics/pharmacology bridge claim for the corpus.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to a community member:
Good day, Doctor. I hope you can read my comment. I'm almost certain that our PSSD is due to something very similar or the same as PFS. I'm taking testosterone (it was below the normal range), my testosterone level has doubled, and the free testosterone is now five times higher, but my libido and desire aren't increasing. A healthy friend is taking testosterone for gym training and is erect all day long with a sky-high libido. Our bodies have testosterone, but our systems don't process it. SSRIs, while we're taking them, make ejaculation difficult due to the increase in serotonin, and they also damage our androgen receptors. When I stopped taking the SSRIs, I was able to ejaculate again, but the rest didn't return (libido, visual arousal, etc.). PS: Now that I'm taking testosterone, when I have a window, it's stronger than before I started. I think it's because with more testosterone in my system, when the door opens, more testosterone enters, and my libido skyrockets. I don't know why the genital numbness occurs. My nerves are fine. Right after ejaculating, my penis experiences the hypersensitivity that occurs after orgasm. But during intercourse, it's numb.
(Parent context recovered from the r.genit.al mirror on 2026-10-07; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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I'm starting to see trends in PSSD genomes, this is one. DBH
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