Diagnostic extremes as recovery markers: unmeasurable 3α, astronomical urinary testosterone — normalization…
u/drwillpowers
r/DrWillPowers2026-04-09T02:31:06Z
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Summary (paraphrased)
Powers gives case notes: one patient with an unmeasurably high 3α value, another with astronomical urinary testosterone — suggesting that normalization of these markers may track recovery, though patient-dependently. He mentions valproic acid (VPA) as "DNA epigenetic fabric softener": with high substrate on board it could induce upregulation of the patient's androgen-metabolism enzymes — but frames this as luck-dependent theorizing that would fail miserably in most cases. He also claims a simple genetic risk test is craftable once all pathways are mapped — the enzyme set is finite (SLCOs, ABCCs, UGTs) — illustrated by pulling example cases "out of a hat" in front of the community, including a 3A-HSD case with high urinary androgens but nearly no 3a metabolites.
Key points (paraphrased)
- Diagnostic extremes as recovery markers: unmeasurable 3α, astronomical urinary testosterone — normalization may track recovery.
- VPA as epigenetic "fabric softener" — luck-dependent, expected to fail in most.
- Genetic risk-screen claim: finite enzyme set (SLCO/ABCC/UGT) makes a test craftable.
- Heterogeneity illustration: high urinary androgens with near-zero 3a metabolites (3A-HSD case).
Why it’s in the corpus
Diagnostic extremes and the VPA epigenetic angle, plus the genetic-screen craftability claim. The 3A-HSD contrast case reinforces that opposite lab extremes fit the same model.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to a removed comment in his "If you have PFS do not panic if you don't end up having abnormal urinary androgens" gallery post (a mild sulfation/glucuronidation-failure case: normal estrogen, low estrone sulfate).
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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