Re: Post accutane syndromepas experience and markers…
u/drwillpowers
r/DrWillPowers2026-08-12T03:31:49Z
Dr Will Powers’ own statements and theorizing
Summary (paraphrased)
In the PAS markers thread, answering what tests a PAS sufferer should pursue, Powers reports a new lead he stumbled on: the constitutive androstane receptor (CAR) dimerizes with the retinoid X receptor (RXR) — a molecular intersection of neurosteroids, androgens, and retinols that could explain how isotretinoin connects to the same pile-up mechanism. He stresses it is unresolved how this intersection would actually produce the accumulation. For testing he recommends whole-genome sequencing, DUTCH, and androgen-metabolite panels per his PFS-risk post.
Key points (paraphrased)
- New mechanistic lead: CAR–RXR dimerization as the intersection of neurosteroids, androgens, and retinols.
- Potential explanation for isotretinoin's connection to the pile-up mechanism.
- Explicitly unresolved how the intersection produces accumulation — flagged as early-stage.
- Test recommendations for PAS: WGS, DUTCH, androgen-metabolite panels.
Why it’s in the corpus
A brand-new mechanistic lead linking the retinoid axis to his framework — the molecular justification for including PAS in the post-drug umbrella. Flagged as early and unresolved, which the corpus should preserve.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to [username removed], who asked what tests would be useful for PAS — symptoms worsening since stopping isotretinoin (flushing, skin sensitivity, joint/muscle issues, fatigue, brain fog, gut issues) — and volunteered as a test subject, in the "Post Accutane Syndrome (PAS) Experience and Markers" thread by [username removed].
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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