Re: Cdg…
u/drwillpowers
r/DrWillPowers2026-10-09T19:25:10Z
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Summary (paraphrased)
Powers quantifies the dose argument against the CDG crash claim: broccoli contains roughly 3.5 g of glucaric acid per kilogram — the precursor to the commercial calcium-D-glucarate salt and the natural beta-glucuronidase inhibitor — so one dinner's broccoli delivers more than the 0.5 g total the patient took over two days. He says he is there to do science rather than deny experiences, but that patients routinely make causation/correlation errors about fluctuating symptoms.
Key points (paraphrased)
- Quantitative claim: broccoli ~3.5 g glucaric acid/kg; patient total 0.5 g over 2 days.
- Framing: "here to do science" vs. denying experiences; correlation/causation errors.
- Leaves the fragile-equilibrium question open — the objection is dose-specific, not mechanism-general.
- 7 upvotes.
Why it’s in the corpus
The quantitative anchor for PRH-1535's dose argument; also noteworthy for what it does NOT deny — he does not rule out that disrupting the gut can shift a fragile equilibrium, only the specific 250 mg/25-day claim. Could merge with PRH-1537 at intake (same thread, adjacent, same dose argument).
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Replies to a commenter proposing a "broken, fragile equilibrium" model — that even long-cleared substances might knock an unstable equilibrium around, with peppermint and ginger cited as mild triggers, and asking whether that is biochemically feasible.
(Comment text and parent context recovered from the r.genit.al mirror on 2026-10-09; post-dates John's 2026-10-07 export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- Powers · Reddit commentCurated Powers pick
Re: Cdg…
u/drwillpowers · r/DrWillPowers
Answering a patient who blamed a two-day, 250 mg course of calcium-D-glucarate taken 25 days earlier for tanked testosterone/estrogen and full-body anhedonia, Powers gives a pharmacokinetic rebuttal: CDG acts for roughly 8 hours by directly inhibiting…
PRH-15352026-10-09T05:08:38ZPFSPSSDPowers Reddit history - Powers · Reddit commentCurated Powers pick
Re: Cdg…
u/drwillpowers · r/DrWillPowers
In the same CDG thread, Powers condenses the dose argument: he does not say CDG cannot do anything — he says it cannot do anything at 250 mg taken 25 days ago, because a single apple delivers more D-glucaric acid than that dose.
PRH-15372026-10-09T19:31:47ZPowers Reddit history - Powers · Reddit commentCurated Powers pick
Re: Theory as to why some people so sensitive to Calcium-D-Glucarate
u/drwillpowers · r/DrWillPowers
Powers reduced calcium D-glucarate's (CDG) action to a single mechanism — inhibition of bacterial beta-glucuronidase — arguing it only matters for patients who actually have substantial beta-glucuronidase activity, using a house-fire/shed-fire analogy. He…
PRH-00522026-09-27T16:15:22ZPFSPSSDPowers Reddit history