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Re: Cdg…

u/drwillpowers

r/DrWillPowers2026-10-10T19:48:29Z

Dr Will Powers’ own statements and theorizing

Paraphrased from his public posts and talks. His mechanistic and genetic claims are unpublished hypotheses — read them as “Powers theorizes…”, not as established fact.

Mentions treatments or doses — not guidance

Recorded as research context only. Nothing here is a recommendation, and some self-experiments described in sources may be dangerous. Talk to a clinician before changing anything.

Summary (paraphrased)

Replying to a user's report of sexual-function collapse after six days of 500 mg/day calcium-D-glucarate (morning erections ceased, libido 2/10 → 0/10, emotional flattening), Powers gives a mechanistic account: CDG inhibits the reabsorption of glucuronide molecules, so sex hormones are lost through the gut; if gonadal production is already impaired, total T/E levels drop. Headed "Collapse of androgen levels."

Key points (paraphrased)

Mechanism stated: CDG inhibits gut reabsorption of glucuronide molecules → enterohepatic loss of sex hormones.
Collapse condition: only when endogenous gonadal production is impaired (two-hit framing).
Directly extends the systems review's steroid-clearance/glucuronidation axis: this is the first Powers statement tying CDG to a mechanism of hormone loss (not just dose math).
2 upvotes — fresh comment, early engagement.

Why it’s in the corpus

A concise mechanistic claim on the glucuronidation axis — CDG's risk framed as a two-hit model (glucuronide-loss rate vs. gonadal replacement capacity). Sits alongside the tranche-3 CDG debunk as the mirror's counterpart: same axis, now a causal mechanism rather than dose arithmetic. Relevant to any causal-pathway branching on post-drug hormonal persistence.

Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.Show

Replies to [username removed] (Oct 9 21:08 UTC) in the "CDG" thread, a self-report of a six-day CDG trial ending in sexual-function deterioration, with the user unsure whether it was psychosomatic. Powers' reply supplies the causal story for the "CDG crash" pattern — the third CDG-thread entry after the tranche-3 dose-debunk thread (PRH-1535–1537).

(Comment text and parent context recovered from the r.genit.al mirror on 2026-10-10; post-dates John's 2026-10-07 export.)

Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.

Summary (paraphrased)

Key points (paraphrased)

Mechanism stated: CDG inhibits gut reabsorption of glucuronide molecules → enterohepatic loss of sex hormones.
Collapse condition: only when endogenous gonadal production is impaired (two-hit framing).
Directly extends the systems review's steroid-clearance/glucuronidation axis: this is the first Powers statement tying CDG to a mechanism of hormone loss (not just dose math).
2 upvotes — fresh comment, early engagement.

Why it’s in the corpus