Re: Cdg…
u/drwillpowers
r/DrWillPowers2026-10-09T19:31:47Z
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Summary (paraphrased)
In the same CDG thread, Powers condenses the dose argument: he does not say CDG cannot do anything — he says it cannot do anything at 250 mg taken 25 days ago, because a single apple delivers more D-glucaric acid than that dose.
Key points (paraphrased)
- Single-apple dose comparison for D-glucaric acid intake.
- Narrow scope of denial: this dose, this interval — not the mechanism itself.
- 9 upvotes.
Why it’s in the corpus
Pairs with PRH-1536; merge candidate at intake.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Replies to a commenter noting PFS patients report crashing off mild triggers (ginger cited) and arguing that disrupting the gut in a sensitized state can cause a crash without deepening the syndrome in the typical anti-androgen pattern — expecting the OP to return to baseline in weeks.
(Comment text and parent context recovered from the r.genit.al mirror on 2026-10-09; post-dates John's 2026-10-07 export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
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Re: Cdg…
u/drwillpowers · r/DrWillPowers
Powers quantifies the dose argument against the CDG crash claim: broccoli contains roughly 3.5 g of glucaric acid per kilogram — the precursor to the commercial calcium-D-glucarate salt and the natural beta-glucuronidase inhibitor — so one dinner's broccoli…
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Re: Theory as to why some people so sensitive to Calcium-D-Glucarate
u/drwillpowers · r/DrWillPowers
Powers reduced calcium D-glucarate's (CDG) action to a single mechanism — inhibition of bacterial beta-glucuronidase — arguing it only matters for patients who actually have substantial beta-glucuronidase activity, using a house-fire/shed-fire analogy. He…
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Re: CDG Theory
u/drwillpowers · r/DrWillPowers
Powers gave a deliberately simple account of calcium D-glucarate: as a beta-glucuronidase inhibitor it causes glucuronidated compounds and catechols to be dumped into the gut and lost rather than reabsorbed, leaving COMT (catechol-O-methyltransferase) with…
COMTHTR2CPRH-05602026PFSPSSDPRSDPowers Reddit history
