Re: Cdg…
u/drwillpowers
r/DrWillPowers2026-10-09T05:08:38Z
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Summary (paraphrased)
Answering a patient who blamed a two-day, 250 mg course of calcium-D-glucarate taken 25 days earlier for tanked testosterone/estrogen and full-body anhedonia, Powers gives a pharmacokinetic rebuttal: CDG acts for roughly 8 hours by directly inhibiting bacterial beta-glucuronidase, which only blocks reabsorption of glucuronidated androgens shed into the gut. He notes it is calcium plus D-glucaric acid, a compound the body also makes endogenously. He frames this as the "lore problem" in PFS/PSSD — patients correlating fluctuating symptoms with unrelated exposures.
Key points (paraphrased)
- Mechanism claim: CDG = direct bacterial beta-glucuronidase inhibition; ~8–12 h elimination.
- Effect scope: only blocks reuptake of glucuronidated androgens in the gut (enterohepatic androgen recycling).
- D-glucaric acid is endogenously produced — dose context matters.
- "Lore problem": false correlation/causation between exposures and fluctuating symptoms.
- 8 upvotes, edited ~2 h after posting.
Why it’s in the corpus
Directly intersects the Oct 9 systems review's glucuronidation axis (MECH entries on bacterial beta-glucuronidase and androgen clearance), which noted "no human data for calcium-D-glucarate on androgen excretion." This is attributed-theorizing counterweight to CDG "crash" anecdotes — valuable for the corpus's safety thread and as a mechanistic/dose argument rather than new human data. Connects to UGT/SULT clearance genes in the library.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Top-level reply to the CDG thread OP ([username removed]): five months of PSSD, took CDG two days at 250 mg about 25 days prior, then saw tanked T/E labs off-TRT — reporting total bodily numbness, blank mind, partial cognition recovery, anhedonia, no libido, and asking for advice.
(Comment text and parent context recovered from the r.genit.al mirror on 2026-10-09; post-dates John's 2026-10-07 export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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