AKR1D1
aldo-keto reductase family 1 member D1
Gene summary
A protein-coding gene on chromosome 7 (steroid hormone synthesis). The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Aldo-keto reductase family 1 member D1
- Function
Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one).
- Subcellular location
Cytoplasm.
- Tissue specificity
Highly expressed in liver. Expressed in testis and weakly in colon.
- Associated conditions
Congenital bile acid synthesis defect 2 (CBAS2).
Source: UniProtKB/Swiss-Prot P51857, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Steroid-synthesis enzymes sit directly on the pathways perturbed by 5-alpha-reductase inhibitors and SSRIs; inherited variation here is a candidate susceptibility factor for persistent post-drug phenotypes.
Written for the whole steroid synthesis family, not for AKR1D1 specifically.
Mentioned in 1 corpus record
- Conference abstract
Novel mechanisms of testosterone detoxification in UGT2B17 gene deletion carriers and androgen activation by gut microbiome
Abdul Basit; John Amory; Cindy Li; Vijay Mettu; Scott Heyward; Parth B. Jariwala; Matthew R. Redinbo; Bhagwat Prasad · The FASEB Journal (Experimental Biology meeting abstract)
Proteomic comparison of human livers from UGT2B17 deletion carriers versus high expressors found upregulation of alternative steroid-metabolizing pathways (AKR1D1, AKR1C4, and related dehydrogenases/alcohol dehydrogenases) in deletion carriers, redirecting…
AKR1C4AKR1D1UGT2B17UGT2B7MECH-0142021Systems review · Oct 2026
Also in steroid hormone synthesis
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steroid 5 alpha-reductase 2
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steroid 5 alpha-reductase 1
chr 5· Steroid synthesis· 17 records - AKR1C2Powers
aldo-keto reductase family 1 member C2
chr 10· Steroid synthesis· 12 records - AKR1C3Powers
aldo-keto reductase family 1 member C3
chr 10· Steroid synthesis· 9 records - CYP17A1
cytochrome P450 family 17 subfamily A member 1
chr 10· Steroid synthesis· 9 records - AKR1C4Powers
aldo-keto reductase family 1 member C4
chr 10· Steroid synthesis· 8 records - AKR1C1Powers
aldo-keto reductase family 1 member C1
chr 10· Steroid synthesis· 7 records - HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
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