Pathway candidateNCBI-verifiedprotein-coding

APOA1

apolipoprotein A1

NCBI Gene: 335 Ensembl GeneCards UniProt: P02647

Pathway candidate — not linked to PFS or PSSD by any record here

APOA1 is in the library because it belongs to the lipid homeostasis family. No study, report or commentary in the corpus names it, so a variant in APOA1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 11 (lipid and cholesterol homeostasis). Encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Apolipoprotein A-I
Function: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Subcellular location: Secreted.
Tissue specificity: Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.
Associated conditions: Hypoalphalipoproteinemia, primary, 2 (FHA2); Hypoalphalipoproteinemia, primary, 2, intermediate (FHA2I); Familial apolipoprotein gene cluster deletion syndrome (FAPLDS); Amyloidosis, hereditary systemic 3 (AMYLD3).

Source: UniProtKB/Swiss-Prot P02647, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Cholesterol is the obligate precursor of all steroid hormones; lipid handling sets substrate supply for steroidogenesis and neurosteroid synthesis.

Written for the whole lipid homeostasis family, not for APOA1 specifically.

Mentioned in 0 corpus records

No corpus record names APOA1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Lipid homeostasis).

Also in lipid and cholesterol homeostasis

All 19 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Apolipoprotein A-I
Function: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Subcellular location: Secreted.
Tissue specificity: Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.
Associated conditions: Hypoalphalipoproteinemia, primary, 2 (FHA2); Hypoalphalipoproteinemia, primary, 2, intermediate (FHA2I); Familial apolipoprotein gene cluster deletion syndrome (FAPLDS); Amyloidosis, hereditary systemic 3 (AMYLD3).