Pathway candidateNCBI-verifiedprotein-coding

DGAT1

diacylglycerol O-acyltransferase 1

NCBI Gene: 8694 Ensembl GeneCards UniProt: O75907

Pathway candidate — not linked to PFS or PSSD by any record here

DGAT1 is in the library because it belongs to the lipid homeostasis family. No study, report or commentary in the corpus names it, so a variant in DGAT1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 8 (lipid and cholesterol homeostasis). Encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Diacylglycerol O-acyltransferase 1
Function (excerpt): Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats. In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage. Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly. In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity).
Pathway: Lipid metabolism; glycerolipid metabolism.
Subcellular location: Endoplasmic reticulum membrane.
Associated conditions: Diarrhea 7, protein-losing enteropathy type (DIAR7).

Source: UniProtKB/Swiss-Prot O75907, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Cholesterol is the obligate precursor of all steroid hormones; lipid handling sets substrate supply for steroidogenesis and neurosteroid synthesis.

Written for the whole lipid homeostasis family, not for DGAT1 specifically.

Mentioned in 0 corpus records

No corpus record names DGAT1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Lipid homeostasis).

Also in lipid and cholesterol homeostasis

All 19 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Diacylglycerol O-acyltransferase 1
Function (excerpt): Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats. In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage. Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly. In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity).
Pathway: Lipid metabolism; glycerolipid metabolism.
Subcellular location: Endoplasmic reticulum membrane.
Associated conditions: Diarrhea 7, protein-losing enteropathy type (DIAR7).