Pathway candidateNCBI-verifiedprotein-coding

APOB

apolipoprotein B

NCBI Gene: 338 Ensembl GeneCards UniProt: P04114

Pathway candidate — not linked to PFS or PSSD by any record here

APOB is in the library because it belongs to the lipid homeostasis family. No study, report or commentary in the corpus names it, so a variant in APOB is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 2 (lipid and cholesterol homeostasis). This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins (LDL), and is the ligand for the LDL receptor. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Apolipoprotein B-100
Function: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
Subcellular location: Cytoplasm; Secreted; Lipid droplet.
Associated conditions: Hypobetalipoproteinemia, familial, 1 (FHBL1); Hypercholesterolemia, familial, 2 (FHCL2).

Source: UniProtKB/Swiss-Prot P04114, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Cholesterol is the obligate precursor of all steroid hormones; lipid handling sets substrate supply for steroidogenesis and neurosteroid synthesis.

Written for the whole lipid homeostasis family, not for APOB specifically.

Mentioned in 0 corpus records

No corpus record names APOB directly yet. It is in the library because it sits in a pathway the corpus tracks (Lipid homeostasis).

Also in lipid and cholesterol homeostasis

All 19 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Apolipoprotein B-100
Function: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
Subcellular location: Cytoplasm; Secreted; Lipid droplet.
Associated conditions: Hypobetalipoproteinemia, familial, 1 (FHBL1); Hypercholesterolemia, familial, 2 (FHCL2).