Pathway candidateNCBI-verifiedprotein-coding

FABP5

fatty acid binding protein 5

NCBI Gene: 2171 Ensembl GeneCards UniProt: Q01469

Pathway candidate — not linked to PFS or PSSD by any record here

FABP5 is in the library because it belongs to the lipid homeostasis family. No study, report or commentary in the corpus names it, so a variant in FABP5 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 8 (lipid and cholesterol homeostasis). Encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Fatty acid-binding protein 5
Function: Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors. Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation.
Subcellular location: Cytoplasm; Nucleus; Synapse; Postsynaptic density; Secreted.
Tissue specificity: Keratinocytes; highly expressed in psoriatic skin. Expressed in brain gray matter.

Source: UniProtKB/Swiss-Prot Q01469, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Cholesterol is the obligate precursor of all steroid hormones; lipid handling sets substrate supply for steroidogenesis and neurosteroid synthesis.

Written for the whole lipid homeostasis family, not for FABP5 specifically.

Mentioned in 0 corpus records

No corpus record names FABP5 directly yet. It is in the library because it sits in a pathway the corpus tracks (Lipid homeostasis).

Also in lipid and cholesterol homeostasis

All 19 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Fatty acid-binding protein 5
Function: Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors. Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation.
Subcellular location: Cytoplasm; Nucleus; Synapse; Postsynaptic density; Secreted.
Tissue specificity: Keratinocytes; highly expressed in psoriatic skin. Expressed in brain gray matter.