Pathway candidateNCBI-verifiedprotein-coding

CHRM2

cholinergic receptor muscarinic 2

NCBI Gene: 1129 Ensembl GeneCards UniProt: P08172

Pathway candidate — not linked to PFS or PSSD by any record here

CHRM2 is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in CHRM2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 7 (neurotransmission). The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Muscarinic acetylcholine receptor M2
Function: Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CHRM2 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G proteins and mediates signaling by inhibiting adenylate cyclase activity.
Subcellular location: Cell membrane; Postsynaptic cell membrane.
Associated conditions: Major depressive disorder (MDD).

Source: UniProtKB/Swiss-Prot P08172, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for CHRM2 specifically.

Mentioned in 0 corpus records

No corpus record names CHRM2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Muscarinic acetylcholine receptor M2
Function: Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CHRM2 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G proteins and mediates signaling by inhibiting adenylate cyclase activity.
Subcellular location: Cell membrane; Postsynaptic cell membrane.
Associated conditions: Major depressive disorder (MDD).