HTR1A
5-hydroxytryptamine receptor 1A
Gene summary
A protein-coding gene on chromosome 5 (neurotransmission). Encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
5-hydroxytryptamine receptor 1A
- Function (excerpt)
G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism.
- Subcellular location
Cell membrane; Cell projection, dendrite.
- Tissue specificity
Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.
- Associated conditions
Periodic fever, menstrual cycle-dependent (PFMC).
Source: UniProtKB/Swiss-Prot P08908, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).
Written for the whole neurotransmission family, not for HTR1A specifically.
Mentioned in 6 corpus records
- Peer-reviewed paperPSSD Discord pick
Post-SSRI Sexual Dysfunction (PSSD): A comprehensive review of epidemiology, pathophysiology, and clinical management
Xie, M.; Huang, P.; Wang, S.; Ma, J.; Zeng, Y.; Sun, J. · Journal (SAGE; 2026)
Systematic review (PubMed/Web of Science/Scopus to April 2024) finding persistent symptoms in up to 74% of affected cohorts beyond 6 months; pathophysiology multifactorial — 5-HT1A desensitization, neurosteroid (allopregnanolone) depletion via 5α-reductase…
HTR1APSSD-0032026PFSPSSDCore corpus - Powers · Reddit commentCurated Powers pick
Re: Why does calcium d glucarate cause anxiety…
u/drwillpowers · r/DrWillPowers
Answer to why calcium D-glucarate causes anxiety. Powers explains it downstream of his core model: buildup of two identified neurosteroids produces chronic GABA-A positive allosteric modulation — like constant endogenous Xanax — forcing downstream systems…
HTR1AHTR2CPRH-01342026-09-16T16:41:07ZPSSDPowers Reddit history - Peer-reviewed paper
Post-SSRI Sexual Dysfunction: A Literature Review
Bala, Areeg; Nguyen, Hoang Minh Tue; Hellstrom, Wayne J. G. · Sexual Medicine Reviews · 6(1):29-34
Comprehensive review of PSSD covering symptoms (genital anesthesia, pleasureless orgasm, low libido, ED), proposed mechanisms (epigenetic gene expression, 5-HT1A downregulation, dopamine-serotonin interactions, hormonal changes, serotonin neurotoxicity) and…
HTR1APSSD-0012018PFSPSSDCore corpus - Timeline event
Standard definitional review of PSSD — genital anesthesia, pleasureless orgasm, persistent low libido — with epigenetic and 5-HT1A theories.
HTR1ATL-2018-01-bala-nguyen-hellstrom-publish-pssd-literature-review-sex2018-01PSSDCore corpus - Glossary term
5-HT1A receptor
receptor
A serotonin autoreceptor whose desensitization/downregulation is a leading mechanistic hypothesis for PSSD, alongside epigenetic changes and hormonal shifts.
HTR1AGL-5-ht1a-receptorPSSDCore corpus - Mechanism
5-HT1A desensitization / serotonergic–dopaminergic imbalance
PFS: suggested · PSSD: supported · PRSD: unstudied
The most PSSD-specific mechanism in the matrix — the one place PSSD evidence outruns PFS evidence.
HTR1AMECH-07PFSPSSDCore corpus
Also in neurotransmission
All 54 genes- SLC6A4
solute carrier family 6 member 4
chr 17· Drug transporters· 10 records - COMT
catechol-O-methyltransferase
chr 22· Drug metabolism· 4 records - HTR2C
5-hydroxytryptamine receptor 2C
chr X· Neurotransmission· 4 records - DBH
dopamine beta-hydroxylase
chr 9· Neurotransmission· 3 records - BDNF
brain derived neurotrophic factor
chr 11· Neurotransmission· 2 records - DRD1
dopamine receptor D1
chr 5· Neurotransmission· 1 record - DRD2
dopamine receptor D2
chr 11· Neurotransmission· 1 record - HTR2A
5-hydroxytryptamine receptor 2A
chr 13· Neurotransmission· 1 record
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