Pathway candidateNCBI-verifiedprotein-coding

CHRM3

cholinergic receptor muscarinic 3

NCBI Gene: 1131 Ensembl GeneCards UniProt: P20309

Pathway candidate — not linked to PFS or PSSD by any record here

CHRM3 is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in CHRM3 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 1 (neurotransmission). The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Muscarinic acetylcholine receptor M3
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subcellular location: Cell membrane; Postsynaptic cell membrane; Basolateral cell membrane; Endoplasmic reticulum membrane.
Associated conditions: Prune belly syndrome (PBS).

Source: UniProtKB/Swiss-Prot P20309, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for CHRM3 specifically.

Mentioned in 0 corpus records

No corpus record names CHRM3 directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

All 54 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Muscarinic acetylcholine receptor M3
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subcellular location: Cell membrane; Postsynaptic cell membrane; Basolateral cell membrane; Endoplasmic reticulum membrane.
Associated conditions: Prune belly syndrome (PBS).