CREB1
cAMP responsive element binding protein 1
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 2 (cell signaling and transcription factors). Encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Cyclic AMP-responsive element-binding protein 1
- Function
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity).
- Subcellular location
Nucleus.
- Associated conditions
Angiomatoid fibrous histiocytoma (AFH).
Source: UniProtKB/Swiss-Prot P16220, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.
Written for the whole signaling & transcription family, not for CREB1 specifically.
Mentioned in 0 corpus records
No corpus record names CREB1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).
Also in cell signaling and transcription factors
All 52 genes- CLOCK
clock circadian regulator
chr 4· Signaling & transcription· Pathway candidate - FOXA1
forkhead box A1
chr 14· Nuclear receptors· Pathway candidate - FOXA2
forkhead box A2
chr 20· Signaling & transcription· Pathway candidate - FOXO1
forkhead box O1
chr 13· Signaling & transcription· Pathway candidate - FOXO3
forkhead box O3
chr 6· Signaling & transcription· Pathway candidate - FOXO4
forkhead box O4
chr X· Signaling & transcription· Pathway candidate - GATA2
GATA binding protein 2
chr 3· Signaling & transcription· Pathway candidate - GATA3
GATA binding protein 3
chr 10· Signaling & transcription· Pathway candidate
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