Pathway candidateNCBI-verifiedprotein-coding

FOXA1

forkhead box A1

Chromosome 14Nuclear receptors Signaling & transcription

NCBI Gene: 3169 Ensembl GeneCards UniProt: P55317

Pathway candidate — not linked to PFS or PSSD by any record here

FOXA1 is in the library because it belongs to the nuclear receptors / signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in FOXA1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 14 (steroid and nuclear hormone receptors, cell signaling and transcription factors). Encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Hepatocyte nuclear factor 3-alpha
Function (excerpt): Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity).
Subcellular location: Nucleus.
Tissue specificity: Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.

Source: UniProtKB/Swiss-Prot P55317, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure. General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole nuclear receptors / signaling & transcription family, not for FOXA1 specifically.

Mentioned in 0 corpus records

No corpus record names FOXA1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors, Signaling & transcription).

Also in steroid and nuclear hormone receptors

All 41 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Hepatocyte nuclear factor 3-alpha
Function (excerpt): Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity).
Subcellular location: Nucleus.
Tissue specificity: Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.

Why its pathway is in the library

Written for the whole nuclear receptors / signaling & transcription family, not for FOXA1 specifically.