Pathway candidateNCBI-verifiedprotein-coding

FOXO1

forkhead box O1

NCBI Gene: 2308 Ensembl GeneCards UniProt: Q12778

Pathway candidate — not linked to PFS or PSSD by any record here

FOXO1 is in the library because it belongs to the signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in FOXO1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 13 (cell signaling and transcription factors). This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Forkhead box protein O1
Function (excerpt): Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity).
Subcellular location: Cytoplasm; Nucleus.
Tissue specificity: Expressed in umbilical endothelial cells (at protein level). Abundantly expressed in skeletal muscle and ovary, with lower expression in the heart, placenta, lung, liver, pancreas, spleen, testis and small intestine. Weakly expressed in the brain, thymus, prostate and mucosal lining of the colon.
Associated conditions: Rhabdomyosarcoma 2 (RMS2).

Source: UniProtKB/Swiss-Prot Q12778, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole signaling & transcription family, not for FOXO1 specifically.

Mentioned in 0 corpus records

No corpus record names FOXO1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).

Also in cell signaling and transcription factors

All 52 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Forkhead box protein O1
Function (excerpt): Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity).
Subcellular location: Cytoplasm; Nucleus.
Tissue specificity: Expressed in umbilical endothelial cells (at protein level). Abundantly expressed in skeletal muscle and ovary, with lower expression in the heart, placenta, lung, liver, pancreas, spleen, testis and small intestine. Weakly expressed in the brain, thymus, prostate and mucosal lining of the colon.
Associated conditions: Rhabdomyosarcoma 2 (RMS2).