Pathway candidateNCBI-verifiedprotein-coding

GATA2

GATA binding protein 2

NCBI Gene: 2624 Ensembl GeneCards UniProt: P23769

Pathway candidate — not linked to PFS or PSSD by any record here

GATA2 is in the library because it belongs to the signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in GATA2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (cell signaling and transcription factors). Encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Endothelial transcription factor GATA-2
Function: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
Subcellular location: Nucleus.
Tissue specificity: Endothelial cells.
Associated conditions: Immunodeficiency 21 (IMD21); Lymphedema, primary, with myelodysplasia (LMPM); Myelodysplastic syndrome (MDS).

Source: UniProtKB/Swiss-Prot P23769, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole signaling & transcription family, not for GATA2 specifically.

Mentioned in 0 corpus records

No corpus record names GATA2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).

Also in cell signaling and transcription factors

All 52 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Endothelial transcription factor GATA-2
Function: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
Subcellular location: Nucleus.
Tissue specificity: Endothelial cells.
Associated conditions: Immunodeficiency 21 (IMD21); Lymphedema, primary, with myelodysplasia (LMPM); Myelodysplastic syndrome (MDS).