Pathway candidateNCBI-verifiedprotein-coding

DDC

dopa decarboxylase

NCBI Gene: 1644 Ensembl GeneCards UniProt: P20711

Pathway candidate — not linked to PFS or PSSD by any record here

DDC is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in DDC is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 7 (neurotransmission). The protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD).

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Aromatic-L-amino-acid decarboxylase
Function: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin (By similarity).
Pathway: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2 (By similarity).
Tissue specificity: Isoform 2: High expression in kidney.
Associated conditions: Aromatic L-amino-acid decarboxylase deficiency (AADCD).

Source: UniProtKB/Swiss-Prot P20711, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for DDC specifically.

Mentioned in 0 corpus records

No corpus record names DDC directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

All 54 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Aromatic-L-amino-acid decarboxylase
Function: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin (By similarity).
Pathway: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2 (By similarity).
Tissue specificity: Isoform 2: High expression in kidney.
Associated conditions: Aromatic L-amino-acid decarboxylase deficiency (AADCD).